toward an integrated anthropology of infant sleep

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steroid side effects BACKGROUND: Despite their widespread use the effects of taking benzodiazepines and non benzodiazepine hypnotics during pregnancy on the risk of major congenital anomaly (MCA) are uncertain. The objectives were to estimate absolute and relative risks of MCAs in children exposed to specific anxiolytic and hypnotic drugs taken in the first trimester of pregnancy, compared with children of mothers with depression and/or anxiety but not treated with medication and children of mothers without diagnosed mental illness during pregnancy.METHODS: We identified singleton children born to women aged 15 "45 years between 1990 and 2010 from a large United Kingdom primary care database. We calculated absolute risks of MCAs for children with first trimester exposures of different anxiolytic and hypnotic drugs and used logistic regression with a generalised estimating equation to compare risks adjusted for year of childbirth, maternal age, smoking, body mass index, and socioeconomic status.RESULTS: Overall MCA prevalence was 2.7% in 1,159 children of mothers prescribed diazepam, 2.9% in 379 children with temazepam steriods, 2.5% in 406 children with zopiclone, and 2.7% in 19 steriods,193 children whose mothers had diagnosed depression and/or anxiety but no first trimester drug exposures. steroid side effects

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